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HAPILA GmbH is a medium-sized, globally active chemical and pharmaceutical company specializing in the development of chemical synthesis and the manufacture of APIs. As an independent company, we offer our customers our many years of experience and proven expertise in the field of active pharmaceutical ingredients as a key component of their drug development and manufacturing processes.

From synthesis development to GMP-compliant active pharmaceutical ingredient - depending on the scope of the project - we support you throughout the entire process, from complex development through scale-up to the manufacture of the GMP-compliant active pharmaceutical ingredient, including, upon request, the development of analytical methods and particle design. Our primary focus is on achieving very high product purity combined with high yield.


We are also happy to support you in developing and preparing regulatory documents and are available to serve as your expert partner for all questions relating to active pharmaceutical ingredients (APIs).


We adapt to your needs and are also available for individual services.

We strive for trust-based cooperation through open communication. When discussing how to solve problems, we show a high degree of flexibility and we are pleased to accommodate your wishes when shaping our collaboration.

We support you with all questions regarding

  • synthesis development, scale-up and GMP manufacturing of active pharmaceutical ingredients including analytical method development and GMP quality control;
  • synthesis, establishment and control of reference substances;
  • synthesis development and GMP manufacturing of active ingredients for clinical samples;
  • synthesis of isotopically labelled substances for in vitro diagnostics;
  • development of purification processes for active pharmaceutical ingredients based on our patented HAPIpur® technology (fully automated continuous multi-stage counter-current crystallization);
  • development of shaping processes (particle design / particle engineering) for active pharmaceutical ingredients for targeted pharmaceutical application on the basis of constructive physical processes;
  • creation of regulatory relevant documents, such as ASMF, IMPD, CEP;
  • creation of safety data sheets according to REACH, TRGS 220 and other documents relevant to hazardous substances, and
  • general handling of active pharmaceutical ingredients.

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